| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives
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| Autores: |
Saleem,Afia
Bukhari,Syed Majid
Zaidi,Asma
Farooq,Umar
Ali,Majid
Khan,Asma
Khan,Sidra
Shah,Kausar Hussain
Mahmood,Adeem
Khan,Farhan Ahmed
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| Data: |
2020-01-01
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| Ano: |
2020
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| Palavras-chave: |
4-Hydroxycoumarin
Anti-urease
Carbonic anhydrase
Aldehydes
Antibacterial
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| Resumo: |
The 4-Hydroxycoumarin derivatives are known to show a broad spectrum of pharmacological applications. In this paper we are reporting the synthesis of a new series of 4-Hydroxycoumarin derivatives synthesized through Knovenegal condensation; they were characterized by using UV-Vis, FT-IR, NMR spectroscopies. The synthesized compounds were evaluated for antibacterial activity against Staphylococcus aureus and Salmonella typhimurium strains. The compounds (2), (3) and (8) showed favorable antibacterial activity with zone of inhibitions 26.5± 0.84, 26.0 ± 0.56 and 26.0 ± 0.26 against Staphylococcus aureus (Gram-positive) respectively. However, the compounds (5) and (9) were found more active with 19.5 ± 0.59 and 19.5 ± 0.32 zone of inhibitions against Salmonella typhimurium (Gram-negative). Whereas, in urease inhibition assay, none of the synthesized derivatives showed significant anti-urease activity; although, in carbonic anhydrase-II inhibition assay, the compound (2) and (6) showed enzyme inhibition activity with IC50 values 263±0.3 and 456±0.1, respectively.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100580
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/s2175-97902019000418654
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.56 2020
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| Direitos: |
info:eu-repo/semantics/openAccess
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